Lymphoma Info

t(8:14)(q24;q32) and t(2;8)(p12;q24)
Translocations between chromosomes 8 and 14 and 2 and 8 are observed in Burkitt’s non-Hodgkins lymphomas and B-cell ALL-L3.  In general, the t(2;8) and t(8;14) neoplasms are aggressive and associated with poor patient prognosis.

t(14;18)(q32;q21)
The t(14;18) has been observed in a wide variety of lymphoid neoplasms, but most often in non-Hodgkin’s lymphomas specifically, the follicular, small cleaved-cell type.  There have been a few reports of the t(14;18) having been found in Hodgkin’s disease.  It is not unusual to observe other chromosome changes associated with the presence of the t(14;18).

Rearrangements of 1q
Rearrangements of the chromosome 1 long arm have been observed in a wide variety of neoplastic and preneoplastic disease, most frequently in acute lymphocytic leukemia and non-Hodgkin’s lymphoma.