Chronic Myelogenous Leukemia (CML) Info

t(9;22)(q34;q11 or 12) Philadelphia Chromosome 
The translocation between chromosome 9 and 22 yielding the Philadelphia chromosome (Ph1) is most consistent with chronic myelogenous (granulocytic) leukemia (CML), although it has also been observed in acute lymphocytic leukemia (ALL). In CML, the Ph1 is reported to indicate a relatively good prognosis, while in ALL it is associated with a relatively poor prognosis. The presence of chromosome changes in addition to the Ph1, e.g. +8, iso(17q),+9, +Ph1, is a indication of a blastic phase of CML and poor patient prognosis.