Oncology Microarray, Oncology Testing Laboratory
Assure™ SNP Microarray utilizes a high resolution single nucleotide polymorphism (SNP) analysis for the detection chromosomal alterations. This permits for accurate detection of both large genome copy-number changes and individual genes associated with cancer. Chronic lymphocytic leukemia (CLL) and myelodysplastic syndromes (MDS) are especially suitable for Assure™ SNP Microarray analysis because of the high incidence of dosage-related clonal changes that have been proven to have an influence on patient outcomes.
Assure™ SNP Microarray detects copy number aberrations seen by karyotype and FISH. Additionally it provides faster, higher-resolution results than standard karyotyping and can help detect clinically significant cryptic aberrations that common FISH panels may not target. Assure™ SNP Microarray quickly identifies copy number changes in hematologic malignancies with a single study.
|Peripheral Blood||5-10 ml||5-10 ml|
|A completed requisition and consent form should be sent with each sample.|
Reporting of Results
- Copy number gain/losses of >50Kb within clinically significant genes or regions
- Copy number loss of >200 kb or gain >500 kb outside known clinically significant regions with at least one OMIM annotated gene or within a region of clear clinical significance
Identification of UPD and consanguinity