Indications For AneuVysion™ Prenatal FISH (13, 18, 21, X, Y)
- Abnormal first trimester screening result
- Advanced maternal age (>35 years of age)
- Previous pregnancy with chromosomal abnormality
- Recurrent spontaneous miscarriage
- Family history of a chromosomal abnormality
- Abnormal maternal serum screening results
- Down Syndrome
- Edwards Syndrome
- Patau syndrome
- Klinefelter syndrome
- Turner Syndrome
- Abnormal ultrasound findings
STAT 24 hour detection of aneuploidy for chromosomes 13, 18, 21, X & Y, via fluorescence in situ hybridization (FISH) assay in interphase cells from prenatal samples. All FISH analysis is confirmed by routine cytogenetic analysis.
- Amniotic fluid Discard the first 2 ml of fluid to reduce the risk of maternal cell contamination. Aseptically transfer the specimen into sterile plastic conical tubes labeled with patient’s name and date of birth.
- CVS Aseptically transfer the specimen into sterile plastic conical tubes containing sterile transport medium (provided by CytoGenX). Label tube with patient’s name and date of birth.
A completed test requisition form must be included with every sample. A transport kit is available upon request.
3- 5cc of amniotic fluid or 3mg of CVS is used for FISH analysis (this is in addition to the normal amount collected for chromosome analysis). This is not a standalone test and must be ordered with standard cytogenetic analysis.
Sterile 15ml screw-cap container
Fluorescence in situ hybridization is performed on interphase cells to detect aneuploidy of chromosomes 13, 18, 21, X & Y. Results are confirmed by cytogenetic analysis.
Room temperature (DO NOT refrigerate, freeze or centrifuge)
Causes for Rejection
Frozen specimen, large amount of blood, inappropriate container
For more information on Fluorescent in Situ Hybridization, Please contact CytoGenx.