Amniotic Fluid Chromosome Analysis

Indications for Amniotic Fluid Chromosomal Analysis

  • Abnormal first trimester screening result
  • Advanced maternal age (>35 years of age)
  • Previous pregnancy with chromosomal abnormality
  • Recurrent spontaneous miscarriage
  • Family history of a chromosomal abnormality
  • Abnormal maternal serum screening results
  • Abnormal ultrasound findings

Specimen Requirements

15-20cc amniotic fluid (less if early amniocentesis)

Collection Procedure

Discard the first 2 ml of fluid to reduce the risk of maternal cell contamination.  Aseptically transfer the specimen into sterile plastic conical tubes labeled with patient’s name and date of birth.  A completed test requisition form must be included with every sample.  A transport kit is available upon request. To learn more about the Amniocentesis lab testing please call us today.                                                                                                                              

Specimen Container

Sterile 15ml screw-cap container

Methodology

In situ culturing of amniocytes to identify both numerical and structural chromosome abnormalities

Transport Temperature

Room temperature (DO NOT refrigerate, freeze or centrifuge)

Causes for Rejection

Frozen specimen, excessive amounts of blood, inappropriate container

Turnaround Time

5-10 days